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来源:9159金沙游艺场科学技术与学科建设处、人才培养处、人力资源处    日期:2013-09-16     浏览次数:
讲座题目
The Glycobiology of the Stem/Progenitor cell niche
主讲人
Professor Bruce Caterson
School of Biosciences, Cardiff University, Cardiff, UK.
讲座时间/地点
2013-9-26周四  14:30-16:00 /9159金沙游艺场多功能厅
讲座领域
糖生物学、细胞外基质生物学
内容概况
This Lecture emphasises the importance of Glycobiology in nature and aims to highlight, simplify and summarise the multiple functions and structural complexities of the different oligosaccharide combinatorial domains that are found in chondroitin sulphate/dermatan sulphate (CS/DS) glycosaminoglycan (GAG) chains. For example, there are 1008 different pentasaccharide sequences possible within CS, DS or CS/DS hybrid GAG chains. These combinatorial possibilities provide numerous potential ligand-binding domains that are important for cell and extracellular matrix interactions as well as specific associations with cytokines, chemokines, morphogens and growth factors that regulate cellular differentiation and proliferation during tissue development; e.g. morphogen gradient establishment. The review provides some details of the large and diverse number of different enzymes that are involved in CS/DS biosynthesis and attempts to explain how differences in their expression patterns in different cell types can lead to subtle but important differences in the GAG metabolism that influence cellular proliferation and differentiation in development as well as regeneration and repair in disease. Our lab was the first to generate and characterise monoclonal antibodies (mAb) that very specifically recognise different ‘native’ sulphation motif/epitopes in CS/DS GAG chains. These monoclonal antibodies have been used to identify very specific spatio-temporal expression patterns of CS/DS sulphation motifs that occur during tissue and organ development (in particular their association with stem/progenitor cell niches) and also their recapitulated expression in adult tissues with the onset of degenerative joint diseases. In summary, diversity in CS/DS sulphation motif expression is a very important necessity for animal life as we know it.
       Reference: Caterson B. (2012). Chondroitin sulphate glycosaminoglycans: fun for some and confusion for others. Int. J. of Exp. Path. 93: 1 – 10
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